Drug Profile: Dopamine
Trade Name: Intropin
Adrenergic agonist, inotropic, vasopressor
Mechanism of Action:
Stimulates the alpha and beta adrenergic receptors. At moderate doses (2-10mcg/kg/min), dopamine stimulates beta1 receptors, resulting in inotropy and increased cardiac output while maintaining dopamonergic-induced vasodilatory effects. At high doses (>10 mcg/kg/min) alpha adrenergic agonism predominates, and increased peripheral vascular resistance and vasoconstriction result.
- Decreased cardiac output associated with cardiogenic shock and septic shock
- Hpotension after ROSC
- Symptomatic bradycardia unresponsive to atropine.
- Severe hypertension
- Nausea and vomiting
- Correct any hypovolemia with fluid replacement before administering dopamine.
Adult- 2 to 20 mcg/kg/min IV/IO infusion. Starting dose 5mcg/kg/min; may gradually increase the infusion by 5-10 mcg/kg/min to desired effect. Cardiac dose is usually 5 - 10 mcg/kg/min; vasopressor dose is usually 10 - 20 mcg/kg/min. Little benefit gained beyond 20 mcg/kg/min.
Pedi - Same as adult
- Do not administer in the same line as alkaline solutions.
- Half-life 1 minute
- Pregnancy class C